mri scan Prostate Cancer"Every man with suspected prostate cancer should have an MRI scan," The Guardian reports. That is the conclusion of a study looking at how well MRI scans compare with the current practice of biopsies; removing sections of prostate tissue for analysis.


Disadvantages of prostate biopsies include the fact that they can lead to a small risk of side effects, some of which can be serious, such as sepsis.


Researchers were looking at an advanced type of MRI scan, known as a multi-parametric MRI, which as well as looking at the shape and size of the prostate, can also assess other factors such as blood flow through the gland.

The scan was used on more than 500 British men. The results suggest that scanning would safely reduce the number of men needing a biopsy by about a quarter. Moreover, in men with an aggressive prostate cancer the combination of MRI scan followed by a biopsy is almost twice as likely to pick up clinically significant cancer.

The National Institute for Health and Care Excellence (NICE) is currently considering this new diagnostic method to decide whether introducing it will be cost-effective.

The study was carried out by researchers from University College London, Royal Marsden Hospital, University of York, Hampshire Hospitals NHS Trust and UCLH NHS Foundation Trust, all in the UK. The study was funded by the UK Government Department of Health, National Institute of Health Research- Health Technology Assessment Programme, UCLH/UCL Biomedical Research Centre, The Royal Marsden and Institute for Cancer Research Biomedical Research Centre. The study was published in the peer-reviewed medical journal The Lancet, on an open-access basis, meaning it is free to read online.  

This was a prospective paired cohort trial known as the Prostate MRI Imaging Study (PROMIS), that recruited men with suspected prostate cancer. All the men would previously have been advised to have a prostate biopsy. Men were each offered two diagnostic tests: the traditional diagnostic test, transrectal ultrasound guided biopsy (TRUS-biopsy) and the new diagnostic test involving multi-parametric magnetic resonance imaging (MP-MRI). The tests were done in addition to a template prostate mapping biopsy (TPM-biopsy). This is a reference standard against which the detection rates of each previous approach could be evaluated. Because both diagnostic tests were performed on each man participating in the trial, they can be directly compared with the reference standard and the benefits of using both in sequence can be evaluated. Cohort studies provide the best evidence when looking at diagnostic tests.

Overall, this study provides good evidence that using an MP-MRI test before a biopsy can result in a much lower proportion of men undergoing unnecessary biopsy. The combination helps detect cancer and avoid unnecessary treatment. However, the lower accuracy of predicting patients without the disease means that patients with a suspicious MP-MRI scan will still need a biopsy. That is because the current results suggest that in cases where the scan gives an "all-clear" there is around a 40% chance that this is actually an incorrect result.

 

There are, however, a few study limitations:

  • The time lag between tests (with the new diagnostic test occurring first) may have meant the nature of the tumour was slightly different by the time the traditional diagnostic test and the reference tests were undertaken.
  • Men with a prostate over 100ml were excluded which may have affected the proportion of accurate diagnoses.
  • The traditional TRUS-biopsy was performed directly after the TPM-biopsy.
  • The accuracy of the traditional test might have been affected by swelling and tissue disruption caused by the prior biopsy.

 

Overall, the findings provide a strong argument for recommending MP-MRI scans for all men with a raised PSA level before having a biopsy. It is reported that NICE are currently considered whether MP-MRI scans should be added to the standard diagnosis of prostate cancer.

 

Source: NHS Choices