Mammad
If the anaesthetic machine is connected and there is some sort of flow (basal or otherwise) going across the cell (sensor) and the concentration is >21% the cell will deteriorate quicker.
Best practise here is that at the end of each working list the machine is disconnected from gases and the gas lines hung over the top of the machine so that whoever uses it next is aware of the disconnection.
Also if the cell is on a flylead connector it can be disconnected in the same way.
Should the machine not be getting used for an extended period its best to remove the cell.