I also like the (so-called) "trim knob"* approach. But I first saw these on
Dräger monitors (back in the mid-1990's). Not a lot of good on infusion pumps, though.

I also like the up and down chevrons on infusion pumps. A pair for each of the hundreds, ten, units (ones?) ... and (if need be) decimal positions.
Meanwhile, I have yet another "well known" pump in front of me now that simply has a
100,
10 and
1 button. Each press on each button increments by 100, 10 or 1 respectively, and then rolls-over to 0 again when you press again at 900, 90 or 9 (if you see what I mean). As always (and as Bruce sings in one of his songs), "you can get used to anything ... sooner or later it just becomes your life"!

* Twiddle and click? Very quick ... just as long as you can see what changes you are scrolling through, and then commiting to. Once again ... feedback!