The biggest threat to patient safety has to be the human factor, attention to detail. If something doesnt feel right it usually is your sixth sense kicking in.
The biggest problem is probably infusion pumps getting programmed wrong as has been in a lot of reports. Simple mathematics and nowadays most pumps ask you to confirm the dose that you are giving. Similar to what they do with drugs (second set of eyes is always a good thing).
Check and check again and if you still are not happy call for a second opinion. Better off being over cautious than cutting corners as the judge will just throw the book at you.